• INCB024360 analogue CYP A is one of the key metabolizing enz

  2023-07-29

  

  CYP3A4 is one of the key metabolizing INCB024360 analogue of the cytochrome P450 (CYP) superfamily of heme-containing monooxygenases. As the CYP family of enzymes plays important roles not only in the xenobiotic metabolism and detoxification of a large number of drugs, but also in the biosynthesis o

• br Discussion The measurement of

  2023-07-29

  

  Discussion The measurement of GYKI 52466 dihydrochloride (FSH, LH) is critical in the evaluation and assessment of 46,XX females presenting with primary amenorrhea and lack of pubertal development. A serum level of FSH higher than 40 U/L is diagnostic of ovarian failure (6), as seen in the prese

• In conclusion we have produced some

  2023-07-29

  

  In conclusion, we have produced some highly potent inhibitors of P450 in comparison to the standard motilin receptor KTZ. Also, due to the limited specificity of these compounds against lyase in comparison to the 17α-OHase component, these compounds would be expected to have a major impact on corti

• glycine transporter br Methods br Results br Discussion Auto

  2023-07-29

  

  Methods Results Discussion Autotaxin has been shown to have effects on major cell types implicated in OA, notably chondrocytes, osteoblasts, osteoclasts, and synoviocytes, through its enzymatic product LPA [20]. However, a paucity of research exists on the involvement of autotaxin in OA. Fi

• Our results showed suppressed autophagy in GECs under HAGG s

  2023-07-29

  

  Our results showed suppressed autophagy in GECs under HAGG stimulation. Recently, people have paid more attentions on the roles of autophagy in lupus and tried to use autophagy regulators for therapy. Rapamycin could prevent the development of nephritis [49] and attenuate the established nephritis [

• Jesus et al discovered a new series of

  2023-07-29

  

  Jesus et al. discovered a new series of azaindole as Aurora inhibitors through various modification of GSK1070916 (47). They synthesized series from modification of the GSK1070916 and evaluated for in-vitro Aurora-B/INCENP and Aurora-A/TPX2 inhibition assays. Modified CVT-313 48 and 49 showed IC50

• GABAB receptor is associated with brain

  2023-07-29

  

  GABAB receptor is associated with STA-21 and behavioral diseases, including epilepsy, spasticity, anxiety and neuropathic pain (Bettler et al., 2004, Bowery et al., 2002, Froestl, 2010). Baclofen, a clinical drug and selective GABAB receptor agonist, is used to treat muscle spasticity in patients w

• Most of lipid lowering agents have many

  2023-07-29

  

  Most of lipid-lowering agents have many therapeutic problems with severe side effects, while dietary fibers as lipid lowering therapy are safer. Chitosan (CS) is a dietary fiber biodegradable, biocompatible and has many health benefits including wound healing, antiinflammatory, anti-cancers, immune-

• br Conclusions In the current study we found

  2023-07-29

  

  Conclusions In the current study, we found that the exposure of maduramicin to chicken myocardial alzheimer's disease results in cellular damage and even death via the induction of apoptosis. Maduramicin upregulated the expression of apoptotic genes and activated caspase cascades, which were acco

• aldehyde dehydrogenase inhibitor Maduramicin is a polyether

  2023-07-29

  

  Maduramicin is a polyether ionophore antibiotic that has the smallest margin of safety between the maximum authorized dosage and the minimum toxic concentration. Clinical signs of maduramicin intoxication are similar to that of other ionophores, often causing feed refusal, anorexia, respiratory dist

• Triacetyl Resveratrol br Results br Discussion Control

  2023-07-29

  

  Results Discussion Control of chronic inflammation is important in several inflammatory conditions like asthma, rheumatoid arthritis and fibrosis in lung diseases. The regulatory pathways that control chronic inflammation are complex and multi-factorial. Over expression of inflammatory mediato

• Since the beginning of s more than

  2023-07-29

  

  Since the beginning of 1990s, more than 17,000 papers about physiological relevance of antioxidants have been published according to data from web of science. Based on the available literature, it seems that assessing the antioxidant potential of food by means of in vitro assays or solely epidemiolo

• Although the earlier studies focused on the antioxidant capa

  2023-07-29

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic Isorhamnetin and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous groups of pl

• Indications that HMGA proteins are

  2023-07-29

  

  Indications that HMGA proteins are involved in regulating the structure and function of large chromatin domains come from the early work of Saitoh and Laemmli [143]. Employing immunolocalization techniques, these workers demonstrated that HMGA1 proteins are co-localized with both histone H1 and the

• br Epidemiology br Genetics The dominantly inherited PrP cer

  2023-07-29

  

  Epidemiology Genetics The dominantly inherited PrP cerebral amyloidoses are genetically transmitted with a penetrance of almost 100%. Early linkage analysis studies helped to established the relationship between GSS and mutations in the PRNP gene. PRNP is located on the short arm of chromosome

14965 records 308/998 page Previous Next First page 上5页 306307308309310 下5页 Last page