• br Materials and Methods br

  2021-05-14

  

  Materials and Methods Author Contributions Conflicts of Interest Acknowledgments This work was sponsored by the National Natural Science Foundation of China (81802517), the Integrated Traditional Chinese and Western Medicine of Shanghai (ZHYY-ZXYJHZX-1-03), the Clinical Research Program

• br Experimental procedures br Results Fluorescence attributa

  2021-05-14

  

  Experimental procedures Results Fluorescence attributable to GnRH-eGFP neurons was observed through the diagonal band of Broca, to the POA of the hypothalamus in GnRH-eGFP transgenic rats for all groups as described previously (Kato et al., 2003, Tada et al., 2013). Discussion The mEPSCs w

• br Acknowledgements This research was supported by

  2021-05-14

  

  Acknowledgements This research was supported by Slovenian Research Agency (ARRS). We thank prof. R. Marinšek Logar for helpful advice, Dr. T. Kranjc for help with data management, N. Vrhovnik and G. Lavrič for technical help with preliminary growth experiments and dr. J. Burkeljca for help with g

• br Materials and methods br Results Overexpression

  2021-05-14

  

  Materials and methods Results Overexpression of KLF2 increased the cell viability and reduced the LDH leakage rate and O2•− and ONOO− generation in H/R HUVEC model. To evaluate the effect of KLF2 on H/R HUVEC injury, KLF2 was overexpressed in HUVECs. Cell viability and extracellular LDH level

• The genes corresponding to TVAG TVAG TVAG

  2021-05-14

  

  The genes corresponding to TVAG_263740, TVAG_487600, TVAG_282090, TVAG_170370, and TVAG_148010 seem to be the less expressed, and undetectable by proteomics approach. In comparison, in other T. vaginalis strains, and experimental conditions, they show very few or null EST's reports [4]. Concludin

• Dysfunction of the ubiquitin proteasome system causes abnorm

  2021-05-13

  

  Dysfunction of the ubiquitin-proteasome system causes abnormal organelle morphology and impairs sperm formation and maturation steps resulting in male infertility [[7], [8], [9]]; this indicates that ubiquitination is essential for spermatogenesis and sperm function during fertilization. β-catenin i

• br Methods br Results br Discussion Preclinical data

  2021-05-13

  

  Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the BAN ORL 24 with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not significan

• Diacylglycerol kinase was one of the hits identified from

  2021-05-13

  

  Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a JNK-IN-7 of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns and functions [61], [62], [63]. Some of

• Timolol Maleate Since these first results KSTD activity has

  2021-05-13

  

  — Since these first results, Δ1-KSTD activity has been identified in many other microorganisms, albeit sometimes with different substrate preferences. For instance, Comamonas testosteroni ATCC 11996 (formerly Pseudomonas testosteroni) is active on several steroid substrates, but it cannot use 11β-h

• Previous and ongoing clinical trials

  2021-05-13

  

  Previous and ongoing clinical trials have been summarized in a recent review (Siaw-Debrah et al., 2017). To our knowledge, there are no ongoing or completed clinical trials focusing on cytokines in ICH. Published studies have focused mainly on cytokine changes in ICH patients (summarized in Table 3)

• The three dimensional crystal structure of Ca loaded

  2021-05-13

  

  The three-dimensional crystal structure of Ca2+ loaded CaM reveals a dumbbell-shaped molecule with two roughly globular lobes, the N- and C-terminal lobes linked by a long solvent-exposed helix, which has been shown by NMR to be non-helical in its central part and flexible in solution [13]. Each glo

• The first transcription factor TF known to interact with one

  2021-05-13

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone Phloretin of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed development

• p-Cresyl sulfate br Introduction The cys loop ligand gated i

  2021-05-13

  

  Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2]. Each subunit that makes up the pentameric LGIC architecture possesses a dicysteine bri

• br Advent of SMEPT br SMEPT

  2021-05-12

  

  Advent of SMEPT SMEPT for localized synthesis of nitric oxide Critical evaluation and outlook Examples discussed in this review present SMEPT as a methodology for localized drug synthesis – a unique opportunity for site specific therapeutic interventions using implantable biomaterials. This

• 5-Formyl-UTP br Guidance of B cell localization by EBI br EB

  2021-05-12

  

  Guidance of B cell localization by EBI2 EBI2 expression and B cell disease Although chemoattractant receptors of the GPR family play essential roles in coordinating the migration of lymphocytes for efficient responses against pathogens, their dysregulation can result in the initiation or progr

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