• br Materials and methods br Acknowledgements SD was supporte

  2020-09-24

  

  Materials and methods Acknowledgements SD was supported by a pre-doctoral research fellowship from the Flanders Agency for Innovation and Entrepreneurship (VLAIO-Flanders, Belgium). YB is supported by a postdoctoral fellowship from Research Foundation Flanders (FWO, Belgium). We thank Isabelle

• CIC mediated chemoresistance is driven

  2020-09-24

  

  CIC-mediated chemoresistance is driven by several factors. In our quest to learn about these, we examined the crucial mediators identified earlier in the regulation of CSC survival and chemoresistance, such as BCL2, cleaved Caspase-3, COX-2, and macrophages. Interestingly, we observed a significantl

• br Materials and methods br Results

  2020-09-24

  

  Materials and methods Results Metabolic stability of compounds was studied by incubation with pooled human liver microsomes. Piperine was the metabolically most stable compound, with a t1/2 of 141min (Fig. 2, and Table 1). SCT-29 and LAU 397 showed t1/2 of approx. 45min, whereas a t1/2 of only

• br Materials and methods br Results

  2020-09-24

  

  Materials and methods Results Discussion We confirmed the published cDNA and protein sequence of feline CSF-1R and stably cloned the cat receptor into the Ba/F3 cell line. Activation of feline CSF-1R by recombinant human CSF-1 was previously tested by Woolford et al. [14]. Expression of onc

• Apart from its high affinity the selection of GW as

  2020-09-24

  

  Apart from its high affinity, the selection of GW2580 as PCP inhibitor lead in our radiotracer development program was motivated by its exceptional selectivity. The observed profound impact of small structural modifications on the selected panel of four kinases tested prompted us to conduct comprehe

• Another question concerns the mechanism

  2020-09-24

  

  Another question concerns the mechanism of PC reduction during the phosphate starvation response. There are at least three main mechanisms of PC depletion: suppression of PC synthesis due to substrate exhaustion, downregulation of PC synthase expression by suppression of gene transcription or intens

• The present findings suggested that

  2020-09-24

  

  The present findings suggested that nsEP inhibited CPG2 via deprivation of zinc ions, with no effect on apoenzyme integrity. Zinc may be removed from CPG2 by the electric forces. Within CPG2, each zinc ion was coordinated by one histidine, one glutamate and one aspartate [6]. The nsEP field can alt

• The Lyapunov exponent plays a key role

  2020-09-24

  

  The Lyapunov exponent, plays a key role in the spectral analysis of the family . Here, S denotes the so-called Szegő transfer matrix, defined by Because the matrices so defined satisfy for , we have for . We define By general considerations, there is a compact set with for μ-a.e. . Moreover, by the

• To simulate the inhibition of

  2020-09-24

  

  To simulate the inhibition of the enzyme by organophosphorus, carbamate insecticides or nerve agents, a reversible cholinesterase inhibitor physostigmine was used for most experiments for safety reasons. However, the results of the measurements were verified using the soman organophosphate, which is

• br Acknowledgements br Introduction Water and electrolytes

  2020-09-24

  

  Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and iMDK governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in cancer cell prolif

• The upregulation of PTGS and PTGS in

  2020-09-24

  

  The upregulation of PTGS1 and PTGS2 in late gestation in mares could be linked to the high levels of estrogens produced by the fetoplacental unit. Estrogens are thought to be effective stimulators of prostaglandin production by potentially up regulating PTGS2 expression. Although a recent publicatio

• The same reservoir of genes is involved in fusions in

  2020-09-23

  

  The same reservoir of Cy5 Firefly receptor is involved in fusions in all types of cancers, which predominantly encode kinases and transcriptional factors [102]. This makes fusion genes potential pan-cancer targets, and renders tumor categorization based on genetic profiling therapeutically reasonabl

• br STAR Methods br Acknowledgments We are

  2020-09-23

  

  STAR★Methods Acknowledgments We are grateful to Amaia Lujambio, James Fagin, and Ramon Parsons for providing cell lines and Evripidis Gavathiotis for critical reading of the manuscript. We would like to thank Saboor Hekmaty for providing expertise with RNA-seq analysis. P.I.P. would like to ac

• Future advances in the in vivo molecular imaging of

  2020-09-23

  

  Future advances in the in vivo molecular imaging of enzyme activity will greatly benefit from the progress towards the quantitative detection of enzymes. Quantitative imaging requires knowledge of both the location and concentration of a specific enzyme, which is dependent on the simultaneous measur

• Regarding eicosanoid production iPLA VIA appears in general

  2020-09-23

  

  Regarding eicosanoid production, iPLA2-VIA appears, in general terms, not to play a major role in mediating this response in innate immunity and inflammation, as evidenced by the large number of studies highlighting the lack of effect of selective inhibition of the enzyme in stimulus-induced AA rele

15012 records 800/1001 page Previous Next First page 上5页 796797798799800 下5页 Last page