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Our current knowledge on autophagy broadly differentiates it
2024-09-19
Our current knowledge on autophagy broadly differentiates it into three types: macroautophagy, microautophagy, and chaperone-mediated autophagy. Macroautophagy mainly involves the sequestration of cytoplasmic contents in a double-walled membrane followed by the fusion with the lysosomes. The lysosom
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br Materials and methods br
2024-09-19
Materials and methods Results Discussion Proteomics analyses generate mountains of data, expression information for hundreds or thousands of proteins in a single experiment (Wojcik and Schächter, 2000). Recently proteomics and bioinformatics provide new understandings about the processes in
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exemplifies three of the compounds investigated in
2024-09-19
exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC casr as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or degradation products. As BL
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In addition to peroxyl radicals the
2024-09-19
In addition to peroxyl radicals, the most found radical forms in biological systems, some of assays took into account other free radicals such as superoxide anion, hydroxyl, hydrogen peroxide, singlet oxygen and peroxynitrite. ORAC procedure was also modified using different radical sources such as
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In Pham et al employed
2024-09-19
In 2014, Pham et al. [22] employed the microsphere-based technology to create a Luminex probe-based assay for the rapid identification of single nucleotide polymorphisms that are known to confer resistance to one or more echinocandins in C. glabrata. The targets for the FKS probes were generated usi
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An important and well documented pathway involved in
2024-09-18
An important and well-documented pathway involved in cellular growth and proliferation is the mTOR-mediated synthesis of proteins and lipids [7,13,14]. Although found to be tissue specific or context specific regulation, it has always been observed that either one or both the mTOR complexes regulate
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Since the introduction of zebrafish into the laboratory many
2024-09-18
Since the introduction of zebrafish into the laboratory, many milestones have been achieved that firmly establish this organism as a prominent genetic model for biology and medicine. Many features make this species an organism of easy maintenance in laboratory which provides advantages to understand
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Tension within the network could be explained by
2024-09-18
Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling apoptosis inducer filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin fila
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ACh induced changes in respiratory
2024-09-18
ACh-induced changes in respiratory frequency could be of interest. They may reveal an important mechanism of respiratory modulation at the caudal NTS level. ACh-induced increases in respiratory frequency within this region have been also reported by Furuya et al. (2014). Changes in respiratory timin
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NSAIDs induce gastrointestinal toxicity and evoke asthma
2024-09-18
NSAIDs induce gastrointestinal toxicity and evoke Teriflunomide by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001; Koeberle and Werz, 201
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Another significant group of reductase inhibitors is the ste
2024-09-18
Another significant group of 5α-reductase inhibitors is the steroidal 3-carboxylic ZM 306416 derivatives (relevant examples in Fig. 5), which were designed to mimic the putative enzyme-bound enolate intermediate. This was achieved by introducing sp2-hybridized centers at C3 and C4 and an anionic ca
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br Viral manipulation of host factors to
2024-09-18
Viral manipulation of host factors to oppose anti-viral autophagy To escape or manipulate autophagy, some viruses developed strategies that are based on the recruitment of host-cell endogenous factors. The non-enveloped double-stranded DNA virus adenovirus is rapidly endocytosed after attachment.
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Additionally we used the predicted Cyp
2024-09-14
Additionally, we used the predicted Cyp19a1b amino 5'-Iodoresiniferatoxin sequence from a number of bony fish species to infer their genetic relatedness and found that R. quelen occupies an ancient position within the Siluriformes group. A phylogenetic tree was constructed and it included both full-
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Most human diseases e g cancer diabetes and neurodegenerativ
2024-09-14
Most human diseases (e.g., cancer, diabetes, and neurodegenerative diseases) are complex and multifactorial. Several investigations in the literature focused on new multi-target drug development, which implies active pharmacophores incorporation in one scaffold (Meunier, 2008, Lazar et al., 2004, Te
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A phase I trial has recently
2024-09-14
A phase I trial has recently evaluated enzalutamide, an anti-androgen agent, in patients with ER- and AR-positive advanced BC to estimate safety and tolerability of enzalutamide therapy alone or in association to anastrozole, exemestane or fulvestrant [65]. The results of major clinical trials with
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